Single protein can lead to new superfoods

Beneficial substances comprise broccoli-derived sulforaphane and quercetin, which is found in high-levels in onions. SummaryA new generation of superfoods that tackle heart disease, diabetes could be developed, thanks to research into a protein... Related ArticlesPeople with diabetes pay little attention to salt warnings: studyFM Arun Jaitley out of hospital, to skip G-20 finance ministers' meetFaster way to create insulin-producing cells for diabeticsMice and men share a diabetes gene: Study
A new generation of superfoods that tackle heart disease and diabetes could be developed, thanks to research into a protein that helps keep cells in our bodies healthy.
Researchers at the University of Warwick found that the protein, called Nrf2, continually moves in and out of the nuclei of human cells to sense the cell's health and vitality.
When Nrf2 is exposed to threats to the cell's health it oscillates faster and activates an increase in the cell's defence mechanism, including raising the levels of antioxidant.
The researchers, from the University's Warwick Medical School, successfully increased the speed of Nrf2's movement by artificially introducing health beneficial substances � potential components of new superfoods.
The beneficial substances comprise broccoli-derived sulforaphane and quercetin, which is found in high-levels in onions.
The team used these insights to develop new food supplements, which are currently being trialled to decrease risk of developing diabetes and heart disease.
The research investigated the ways in which compounds in fruit and vegetables keep humans healthy.
The research team is the first to record the continual movement cycle of Nrf2, which sees the protein oscillate in and out of the cell nucleus once every 129 minutes.
When stimulated by a health beneficial vegetable-derived substance Nrf2's cycle sped up to 80 minutes.
"The way Nrf2 works is very similar to sensors in electronic devices that rely on continual reassessment of their surroundings to provide an appropriate response," lead researcher Professor Paul Thornalley said.
"The health benefit of Nrf2 oscillating at a fast speed is that surveillance of cell health is increased when most needed, that is, when cells are under threat.
"By understanding how this process works and increasing Nrf2's speed without putting cells under threat, new strategies for design of healthier foods and improved drugs can be devised. Current designs may have selected substances with suboptimal if not poor health benefits in some cases," Thornalley said.

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